I have noticed a huge improvement in my cystic/nodular acne, taking five of these B5 tablets a day, in conjunction with one L-Carnitine and one B3 tablet. All my active acne has virtually disappeared and I am just left with scarring. Highly recommended as an acne treatment. I think it should be clinically trialled with Accutane, the strong acne medication that can have horrible side effects. B5 works essentially the same way (reducing oil production, improving the skin barrier) but is far better for the body.